This project will control invasive mussels and potentially expand control possibilities throughout the Great Lakes basin through a new approach to Zequanox application, a biological control product specific to zebra and quagga mussels. Local organizations will partner with researchers and consultants to apply Zequanox, evaluate control efficacy, and assess environmental responses using a new non-enclosed approach. The project will control three acres of invasive mussels and provide the necessary information for determining viability of large-scale Zequanox application and native species restoration. The project will educate and involve, and inform stakeholders throughout the Great Lakes via an Invasive Mussel Collaborative webinar.