It was my purpose to relate hypolimnetic oxygen deficits among the depressions of multiple depression Douglas Lake, Michigan to detect spatial variation in production and/or allochthonous organic matter input. I attempted to answer three questions. (1) Are there differences in hypolimnetic oxygen deficits among the depressions relatable to known factors of human lake and lake-shore use? (2) Is the hypolimnetic oxygen deficit within each depression correlated with the standing crop of organic matter? And (3) is the eutrophication rate proceeding at a constant or an accelerating rate within one well-studied depression, South Fishtail Bay, as compared with historical data from Welch and others (Bazin & Saunders, 1971)? My hypothesis was that the concentration of cultural activities at the western end would result in increased rates of primary production in this portion of the lake due to nutrient stimulation from run off of fertilizers and septic tank seepage. I also expected that land clearing, and other cultural activities would increase the allochthonous input to this portion. These activities should produce greater hypolimnetic oxygen deficits in depressions near the western end of lake with smaller deficits occurring in depressions at the remote eastern end of the lake.